This storyline aligns with the Next Generation Science Standards at MS-LS3-1.
Download printable vocabulary cards that tie into this storyline!
This storyline concerns inherited illnesses and contains a social justice component that explains why some genetic illnesses are more prevalent in certain ethnic groups.
Enter your information to receive the teacher guide for this storyline with detailed standards, game storyline walkthrough, in-class activities to supplement the learning, and more!
Arthur decides to look into his family history to see where these sickled cells may have come from. Sure enough, the sickle cell gene is present in Arthur's family. Students learn that while sickle cell anemia requires two sickle cell alleles to present all of its symptoms, people who have only one allele--carriers--can still experience sickle cell symptoms under certain circumstances.
Students compare areas of the world that experience high rates of malaria with areas of the world where sickle cell is most common, and learn that sickle cell carriership actually provides partial immunity against this even deadlier disease. Students also learn that this phenomenon isn't confined to Sub-Saharan Africa; cystic fibrosis, which is most commonly seen in Caucasians, may have risen to prominence in response to the European tuberculosis epidemics of the 1800s.